4.7(77,681)Amazon rating$28.4910,000+ bought last month
Our verdict
This 1.25 oz Zymox Otic Enzymatic Solution adds 1% hydrocortisone to the brand's enzyme-based formula for extra itch relief, and with 77,681 reviews at a 4.7 star average it's the most reviewed and highest-rated ear product in this lineup.
Dogs dealing with itchy ear irritation who could benefit from added hydrocortisone on top of Zymox's enzyme-based approach.
Skip if
Your vet has advised against hydrocortisone for your dog's specific situation, or you'd rather use the same enzyme formula without a steroid ingredient.
Priced 68% above the category median ($16.99 across 63 tracked models)
Our scorecard
4.7/5overall
Owner rating4.7/5
4.7 average across 77,681 owner ratings
Popularity5.0/5
77,681 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 1.25 oz Zymox Otic Enzymatic Solution builds on the brand's core enzyme-based approach by adding 1% hydrocortisone, aimed at helping with itch relief for dogs and cats. It's positioned as the go-to option in Zymox's Otic lineup for owners who want that extra itch support.", "It's essentially the hydrocortisone-added counterpart to Zymox's standard Otic solution, so it's aimed at dogs whose ears show ongoing itching or irritation alongside whatever the enzyme system is working to help address. This is a topical management product, not a substitute for a vet's diagnosis of an underlying condition.", "At $28.49, it's priced above the basic cleaners in this category, but with a 4.7 star average across 77,681 reviews and roughly 10,000 units bought in the past month, it's by far the volume leader among the ear care products reviewed here."]
Pros
Massive review base of over 77,000 with a 4.7 star average, among the strongest track records in ear care
Combines Zymox's enzyme-based approach with 1% hydrocortisone for itch relief
High monthly purchase volume points to strong repeat demand
Compact 1.25 oz size suits routine, once-daily use
Cons
Contains a steroid ingredient, hydrocortisone, so it may not suit dogs who need a steroid-free option
Limited product detail available beyond the listing title and core stats
Higher price point than the basic cleaners in this category
Performance notes
This version pairs Zymox's enzyme-based Otic formula with 1% hydrocortisone, included specifically to help with itching alongside the irritation the enzyme system is designed to target. That combination is likely a big part of why this is the most reviewed product in the category.
What buyers say
With 77,681 reviews at a 4.7 star average and an estimated 10,000 units bought in the past month, this is the clear volume and satisfaction leader among the ear care products reviewed here.
The 1% hydrocortisone is included to help with itch relief alongside the enzyme-based solution. It's not a substitute for veterinary care, so it's worth asking a vet if symptoms don't improve.
How does this compare to the version without hydrocortisone?
Zymox sells both versions of this Otic solution. This one adds 1% hydrocortisone for extra itch relief, while the other version leaves that ingredient out for owners who prefer to avoid steroids.
Why does this product have so many more reviews than others in the category?
At over 77,000 reviews, it's the most reviewed ear care product covered here, which typically reflects a long time on the market combined with strong repeat purchases.
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