4.7(14,770)Amazon rating$33.4920,000+ bought last month
Our verdict
Zymox Advanced Formula Otic Plus is the brand's step-up enzymatic ear solution with 1% hydrocortisone, in a 1.25 oz (37 mL) bottle, and it's earned a 4.7 star average across 14,770 reviews with an especially high monthly purchase volume.
Dogs needing a stronger, once-daily enzymatic ear solution with hydrocortisone included, especially if the standard Zymox Otic formula hasn't been enough.
Skip if
Your dog is already doing well on the basic Zymox Otic formula, or your vet has recommended avoiding hydrocortisone for your dog's specific case.
Weight 1.3 Ounces
Priced 97% above the category median ($16.99 across 63 tracked models)
Our scorecard
4.7/5overall
Owner rating4.7/5
4.7 average across 14,770 owner ratings
Popularity4.7/5
14,770 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 1.25 oz (37 mL) Zymox Advanced Formula Otic Plus solution builds on the brand's core enzyme system by adding 1% hydrocortisone, labeled for all life stages in dogs and cats.", "It's applied once daily for about 7 days to an unwashed ear, massaged in and left to work while your dog shakes out the excess. The label also points owners toward following up with the standard Zymox Otic solution to flush the ear once this course is finished, if needed.", "At $33.49, it's priced at the premium end of this list, but with 14,770 reviews at a 4.7 star average and roughly 20,000 units bought in the past month, it's the single highest-volume seller among the ear care products reviewed here."]
Pros
Advanced formula step-up from the standard Otic solution, with 1% hydrocortisone included
Once-daily application for a full week
4.7 star rating across nearly 15,000 reviews
By far the highest monthly purchase volume in this ear care lineup
Cons
Priced higher than the standard Otic solution and most other cleaners in this list
Contains hydrocortisone, so it isn't the right pick if you're avoiding steroid ingredients
Label suggests a follow-up flush with a separate Zymox Otic bottle, meaning a possible extra purchase
Specifications
Weight
1.3 Ounces
Performance notes
This Advanced Formula version pairs Zymox's enzyme system with 1% hydrocortisone in a 1.25 oz (37 mL) bottle, applied once daily for about a week to an unwashed ear. The label also points owners toward following up with the standard Zymox Otic solution to flush the ear after finishing this course, suggesting it's designed as part of a two-step routine rather than a stand-alone product.
What buyers say
With 14,770 reviews at a 4.7 star average and an estimated 20,000 units bought in the past month, this is the highest-volume product among the ear care items covered here, pointing to strong trust in the Zymox name.
How is this different from the standard Zymox Otic solution?
This Advanced Formula Otic Plus version steps up from the standard Otic line and includes 1% hydrocortisone for added itch relief, applied once daily for about a week.
Do I need to clean my dog's ear before applying this?
No, the directions call for applying it to an unwashed ear, massaging it in, then letting your dog shake out the excess, similar to Zymox's other Otic solutions.
What should I do after finishing the 7-day course?
The label suggests following up with the standard Zymox Otic solution to flush the ear if needed, so you may want to have that on hand once this course is finished.
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