Pet Honesty Chlorhexidine Cat & Dog Seasonal Itch Relief Shampoo, for Allergies, Itching, Skin and Coat Supplement, Helps Shedding, Hot Spots, Deodorizing Dog Shampoo & Grooming Supplies,16oz Review
By Dr. Lena Ortiz · Canine wellness writer · Published 2026-06-05 · Updated 2026-06-24
4.6(13,100)Amazon rating$22.9910,000+ bought last month
Our verdict
This 16oz shampoo pairs chlorhexidine gluconate with ketoconazole, two ingredients commonly used in medicated pet washes, in a cucumber melon formula that has earned a 4.6 star average across more than 13,000 reviews and ranks #4 in its category on Amazon.
Dogs and cats dealing with seasonal itching, hot spots, or shedding who need a medicated wash between vet visits.
Skip if
You want a fully natural formula, since this one includes synthetic dye (FD&C Red 40) and preservatives alongside the active ingredients.
Form Liquid
Benefits Cleansing
Priced 35% above the category median ($16.99 across 131 tracked models)
Our scorecard
4.6/5overall
Owner rating4.6/5
4.6 average across 13,100 owner ratings
Popularity4.5/5
13,100 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog and cat food, health, gear and grooming we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 16 fluid ounce shampoo is built around two active ingredients, chlorhexidine gluconate at 2% and ketoconazole at 1%, blended into a cucumber melon scented base with added aloe vera gel. It's labeled for both cats and dogs and carries a non-GMO claim on the packaging.", "The label markets it for seasonal itch relief, hot spots, and shedding, and it's recommended for use on rashes. It isn't a substitute for veterinary care, but the two named actives are ingredients commonly found in medicated pet shampoos meant to support skin comfort during flare ups.", 'At $22.99 for the 16oz bottle, it sits in the mid-range for a targeted formula. It has built a large following, ranking #4 in dog shampoos with 13,100 reviews averaging 4.6 stars and roughly 10,000 units bought in the past month.']
Pros
Contains chlorhexidine gluconate and ketoconazole, two actives often used in medicated pet shampoos
Formulated for both cats and dogs
Added aloe vera gel for skin comfort
Non-GMO labeling
4.6 star average across 13,100+ reviews, ranked #4 in dog shampoos
Cons
Contains FD&C Red 40 synthetic dye, not ideal if you want a dye-free formula
Also lists methylchloroisothiazolinone and methylisothiazolinone preservatives that some sensitive dogs react to
Not a substitute for a vet visit if itching or hot spots persist
Specifications
Form
Liquid
Benefits
Cleansing
Performance notes
The formula centers on chlorhexidine gluconate 2% and ketoconazole 1% built into a liquid base with cucumber melon fragrance and aloe vera gel, and it's labeled for use on rashes, hot spots, and general itching in both cats and dogs. The bottle isn't oversized at 16 fluid ounces, so a household bathing more than one dog regularly will go through it fairly quickly.
What buyers say
With over 13,100 ratings and a 4.6 star average, plus roughly 10,000 units bought in the past month, this is one of the higher-volume medicated shampoos in the category, suggesting consistent repeat purchases from owners managing ongoing skin issues.
The formula's two listed active ingredients are chlorhexidine gluconate at 2% and ketoconazole at 1%, combined with a cucumber melon scented base and aloe vera gel.
Is it safe for cats too?
Yes, the label lists both cats and dogs as target species, so the same bottle can be used across a multi-pet household.
Will this shampoo cure hot spots or skin infections?
No shampoo can promise that. This one is marketed to help with occasional itching, hot spots, and shedding, but persistent or worsening skin issues should be checked out by a vet rather than managed with shampoo alone.
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