4.7(1,900)Amazon rating$19.73200+ bought last month
Our verdict
Zymox Shampoo is a gentle, enzyme-based option built for dogs dealing with itching, dandruff, or general skin irritation, and its 4.7 star average makes it one of the more trusted picks for sensitive skin.
Dogs with itchy, flaky, or irritated skin who need a soap-free wash without harsh detergents or chlorine.
Skip if
Your dog has healthy skin already and you just want a basic everyday cleaning shampoo without added actives like zinc.
Form Liquid
Benefits Itching,Soothing,Dandruff,Nourishing
Weight 6.7 Ounces
Priced 16% above the category median ($16.99 across 131 tracked models)
Our scorecard
4.7/5overall
Owner rating4.7/5
4.7 average across 1,900 owner ratings
Popularity2.7/5
1,900 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog and cat food, health, gear and grooming we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 12 oz bottle of Zymox Shampoo is built around the brand's enzyme system, paired with zinc as a special ingredient, and positioned for itching, dandruff, and general soothing rather than just cosmetic cleaning. It's labeled allergen-free and formulated with no harsh detergents, no chlorine, and no petroleum by-products, which is a plus for dogs that react to stronger commercial shampoos.", "The liquid formula comes in a pleasant scent, so it doesn't rely on a heavy fragrance to mask odor. It's approved for both dogs and cats, which makes it a useful multi-pet option in households with more than one type of animal to bathe.", 'At $19.73 for 12 fluid ounces, it sits in the mid-range for specialty skin shampoos. With nearly 2,000 reviews and a 4.7 star average, plus around 200 bought in the past month, it has a solid, consistent track record among owners dealing with itchy or flaky dogs.']
Pros
Enzyme-based formula with zinc targeted at itching and dandruff
No harsh detergents, chlorine, or petroleum by-products
Allergen-free labeling for sensitive skin
Works for both dogs and cats
Strong 4.7 star rating across nearly 2,000 reviews
Cons
12 oz bottle is on the small side for larger dogs or frequent bathing
Zinc and enzyme actives make it more of a targeted treatment than an everyday wash
Mid-range price compared to basic drugstore dog shampoos
Specifications
Form
Liquid
Benefits
Itching,Soothing,Dandruff,Nourishing
Weight
6.7 Ounces
Performance notes
The combination of an enzyme system with zinc is aimed squarely at dandruff and itch relief rather than just lathering and rinsing, so it may help support healthier looking skin over repeated use rather than delivering an instant fix. Being free of harsh detergents and chlorine also means it's less likely to strip natural oils, which matters for dogs already dealing with dry or flaky skin.
What buyers say
Nearly 2,000 reviews at a 4.7 star average, with about 200 bought last month, points to a steady base of repeat buyers who reach for this specifically when their dog's skin needs extra care.
Yes, the product is labeled for both cats and dogs, so it works as a shared option in multi-pet households.
Is this shampoo meant for everyday use or just when skin issues flare up?
It's formulated around itching, dandruff, and soothing benefits, so it's best suited to dogs with ongoing skin sensitivity rather than as a plain everyday wash for a dog with no skin concerns.
Does it contain fragrance that could bother sensitive dogs?
It carries a pleasant scent, but the formula is built around gentle, allergen-free ingredients, so most sensitive dogs should tolerate it well. If your dog reacts to any fragrance, patch test a small area first.
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