4.1(3,660)Amazon rating$37.972,000+ bought last month
Our verdict
Vetoquinol Zylkene's small dog capsule delivers 75 mg of alpha-casozepine from hydrolyzed milk protein in a non-drowsy, lactose-free format sized for cats and dogs between 11 and 22 pounds, and a 4.1 star average across 3,660 reviews suggests it's a trusted pick for occasional anxiety around specific events.
Small dogs weighing 11 to 22 pounds facing occasional stress from boarding, vet visits, or celebrations, especially owners who want a non-drowsy, lactose-free capsule rather than a flavored chew.
Skip if
Your dog weighs more than 22 pounds since this dose is sized for smaller dogs, or you're looking for a chewable treat instead of a capsule.
Priced 58% above the category median ($23.99 across 63 tracked models)
Our scorecard
4.1/5overall
Owner rating4.1/5
4.1 average across 3,660 owner ratings
Popularity4.0/5
3,660 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 30 capsule box of Vetoquinol Zylkene is built around 75 mg of hydrolyzed milk protein (bovine) providing alpha-casozepine, dosed specifically for small cats and dogs between 11 and 22 pounds. It's labeled non-drowsy and lactose-free, which sets it apart from sedating options in the calming category.", 'The brand positions this capsule for behavior support and occasional anxiety tied to specific events like boarding, vet visits, and celebrations, rather than an everyday supplement. Vetoquinol also sells a higher dose 450 mg version of Zylkene for larger dogs, so this smaller capsule is specifically calibrated for the 11 to 22 pound range.', 'At $37.97 for 30 capsules, this is priced at the premium end of the calming supplement category. With 3,660 reviews and a 4.1 star average, it has a solid and consistent following among owners of smaller dogs.']
Pros
75 mg alpha-casozepine dose sized for small dogs
Non-drowsy and lactose-free formula
Marketed for specific stress events like boarding and vet visits
Strong 4.1 star average across 3,660 reviews
Cons
Premium price point relative to chew based competitors
Only sized for the 11 to 22 pound weight range, not larger dogs
Capsule format may be less convenient than a flavored soft chew for some dogs
Specifications
Form
Capsule
Flavor
Milk
Benefits
Anxiety Relief,Promote Relaxation,Reduce Stress
Best for
Anxiety, Moving, Stress, Thunderstorms
Breed size
Small
Performance notes
The alpha-casozepine derived from hydrolyzed milk protein is dosed at 75 mg specifically for the 11 to 22 pound weight class, and the non-drowsy, lactose-free formulation is aimed at situational anxiety rather than sedation.
What buyers say
With 3,660 reviews and a 4.1 star average, plus roughly 2,000 units bought in the past month, this small dog capsule has an established and steady base of repeat buyers.
Is this the same dose as the larger Zylkene product?
No, this capsule delivers 75 mg of alpha-casozepine and is sized for dogs 11 to 22 pounds, while Vetoquinol's larger dog version uses a higher 450 mg dose.
Will this make my dog drowsy?
The label describes it as non-drowsy, meaning it's meant to ease stress without sedating your dog, though you should talk to your vet about what to expect for your specific dog.
What situations is this capsule meant for?
Vetoquinol markets it for occasional anxiety tied to events like boarding, vet visits, and celebrations rather than as a daily long term supplement.
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