Zesty Paws Probiotics for Dogs - Digestive Enzymes for Gut Flora, Digestive Health, Diarrhea & Bowel Support - Clinically Studied DE111 - Dog Supplement Soft Chew for Pet Immune System - Pumpkin, 90ct Review

4.5 (26,130) Amazon rating$32.9710,000+ bought last month

Our verdict

Zesty Paws Probiotics for Dogs is a pumpkin flavored soft chew built around the clinically studied strain DE111 along with prebiotics, and its 4.5 star average across more than 26,000 reviews makes it one of the most proven, high-volume probiotics in this collection.

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Best for

Owners who want a well-established, high-review-count probiotic chew backed by a named, clinically studied strain.

Skip if

You're looking for a bare-bones, low-cost option, since this sits toward the higher end of the price range for a probiotic chew.

  • Form Soft Chew
  • Flavor Pumpkin
  • Best for Stomach
  • Weight 12.7 Ounces
  • Priced 32% above the category median ($24.99 across 128 tracked models)

Our scorecard

4.5/5 overall
  • Owner rating4.5/5

    4.5 average across 26,130 owner ratings

  • Popularity5.0/5

    26,130 owner reviews, more than most models here

The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.

Overview

["This 90 count jar from Zesty Paws combines prebiotics and probiotics with glycerin and pumpkin in a soft chew format, built around the clinically studied strain DE111 for gut flora, digestive health, and bowel support. It's marketed toward supporting the immune system as well, since a large share of immune function is tied to gut health.", "The pumpkin flavor and soft chew format are designed to make daily dosing simple, and naming a specific clinically studied strain rather than a generic probiotic blend gives shoppers a concrete reason to trust the formula's mechanism.", "At $32.97 for the 90 count jar, it's priced at the premium end of the category, but its numbers back it up: 26,130 reviews at a 4.5 star average, roughly 10,000 bought in the past month, and a rank of number 2 in Dog Digestive Remedies and top 150 across all of Pet Supplies on Amazon."]

Pros

  • Built around the clinically studied probiotic strain DE111
  • Combines prebiotics and probiotics for gut flora support
  • Pumpkin flavored soft chew, 90 count supply
  • Exceptionally high review volume at 26,130 reviews and a 4.5 star average
  • Ranks number 2 in Dog Digestive Remedies on Amazon

Cons

  • Priced at the higher end for a probiotic chew
  • Detailed CFU count per chew is not listed on this product page
  • Some dogs may not take to the pumpkin flavor as readily as others

Specifications

Form
Soft Chew
Flavor
Pumpkin
Best for
Stomach
Weight
12.7 Ounces

Performance notes

DE111 is called out by name as a clinically studied strain, which sets this apart from probiotic chews that only list a generic blend, and the added prebiotics are meant to help feed and support that bacterial population once it's in the gut. The pumpkin and glycerin base keeps the chew soft and easy to give daily alongside the active ingredients.

What buyers say

With 26,130 reviews averaging 4.5 stars and about 10,000 bought in the past month, this is one of the highest-volume, most consistently well-reviewed probiotics in this collection, reflected in its number 2 rank in Dog Digestive Remedies.

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Frequently asked questions

What makes DE111 different from a generic probiotic blend?

DE111 is named specifically on the label as a clinically studied strain, which gives shoppers more transparency than a chew that only lists a vague probiotic blend without naming the strain.

How often should this be given?

It's formulated as a daily soft chew for ongoing gut flora and digestive support rather than an as-needed remedy, so consistent daily use is how it's intended to be used.

Is this good for dogs with sensitive digestion?

The formula is aimed at supporting gut flora, digestive health, and bowel regularity broadly, but if your dog has a diagnosed digestive condition, check with your vet on whether this fits alongside their care plan.

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