Nutramax Denamarin for Dogs, Liver Health Supplement with S-adenosylmethionine (SAMe) plus Silybin, Liver Support for Dogs, Chewable Tablets, 75 Count Review
By Marcus Bell · Dog nutrition editor · Published 2026-06-15 · Updated 2026-06-30
4.5(4,600)Amazon rating$91.991,000+ bought last month
Our verdict
Denamarin is Nutramax's liver support supplement, combining SAMe and a silybin-phosphatidylcholine complex in chewable tablets, and with roughly 4,600 reviews averaging 4.5 stars, it has built a strong reputation, particularly among owners managing a dog's liver health under veterinary guidance.
Dogs with liver health concerns where a vet has recommended ongoing nutritional support alongside their care plan.
Skip if
You're looking for general digestive or probiotic support rather than a targeted liver supplement, or you haven't discussed liver-specific supplementation with your vet.
Form Tablet
Flavor Liver
Benefits Antioxidant
Best for Liver Function
Weight 0.18 G
Priced 268% above the category median ($24.99 across 128 tracked models)
Our scorecard
4.5/5overall
Owner rating4.5/5
4.5 average across 4,600 owner ratings
Popularity4.2/5
4,600 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This formula centers on S-adenosylmethionine, listed at 225 milligrams, alongside a silybin-phosphatidylcholine complex providing 24 milligrams of silybin A and B, ingredients associated with liver support in veterinary nutrition. It's delivered as a liver flavored chewable tablet, with 75 tablets per bottle.", 'At $91.99, this is the most expensive product in this batch, reflecting its positioning as a targeted, veterinary-oriented supplement rather than a general digestive aid. The label lists it as having antioxidant benefits tied to liver function support.', 'With about 4,600 reviews averaging 4.5 stars and roughly 1,000 units bought in the past month, this has a solid, consistent track record among owners using it as part of a broader liver health plan for their dogs.']
Pros
Combines SAMe and a silybin-phosphatidylcholine complex in one chewable tablet
Strong 4.5 star average across roughly 4,600 reviews
Liver flavored chewable tablets that are typically easier to give than plain pills
75 count bottle offers a substantial supply per purchase
Cons
Significantly more expensive than other supplements in this category at $91.99
Not a digestive or probiotic product, so it won't help with gut health or diarrhea
Best used under veterinary guidance rather than as a general wellness add-on
Specifications
Form
Tablet
Flavor
Liver
Benefits
Antioxidant
Best for
Liver Function
Weight
0.18 G
Performance notes
SAMe and silybin, the two active ingredients here, are commonly used in veterinary nutrition to help support liver function and provide antioxidant activity, a different mechanism entirely from probiotics or digestive enzymes, so this supplement is formulated for a specific liver support role rather than general digestion.
What buyers say
With about 4,600 reviews averaging 4.5 stars and roughly 1,000 units bought last month, this supplement has a steady, loyal following, consistent with a product often used as part of an ongoing, vet-guided care plan rather than an impulse purchase.
No, this is a liver support supplement built around SAMe and silybin, not a probiotic. It's meant to help support liver function rather than gut bacteria or digestion.
Can I give this to my dog without talking to a vet first?
It's best to check with your vet before starting a liver support supplement, especially since it's often used alongside a broader care plan for dogs with liver health concerns.
Why is this priced higher than other supplements in this category?
Denamarin is a targeted formula built around SAMe and a silybin-phosphatidylcholine complex, ingredients associated with veterinary liver support, which typically cost more to source and formulate than general digestive or probiotic ingredients.
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