VetriScience Same Liver Health Tablets, 225 mg S-Adenosyl-Methionine Liver Health and Detox Supplement for Medium and Large Breed Dogs, Glutathione Antioxidant Liver Support, 30 Count Review
By Marcus Bell · Dog nutrition editor · Published 2026-05-08 · Updated 2026-07-01
A vet-formulated SAMe liver support tablet for medium and large dogs, delivering a specific dose alongside glutathione, and backed by nearly 600 reviews at 4.4 stars.
Medium to large breed dogs whose vet has recommended liver support, or owners managing a dog's liver health alongside veterinary care.
Skip if
You have a small breed dog, since this is formulated for medium and large breeds, or your dog has a diagnosed liver condition that needs a vet-directed treatment plan rather than a supplement alone.
Form Tablet
Flavor Unflavored
Benefits Immune Support
Best for Stomach
Breed size Large
Weight 1.76 Ounces
Priced 21% above the category median ($23.95 across 26 tracked models)
Our scorecard
4.4/5overall
Owner rating4.4/5
4.4 average across 591 owner ratings
Popularity3.6/5
591 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
VetriScience's Vetri-SAMe tablets deliver 225 mg of S-Adenosyl-Methionine (SAMe) and 20 mg of L-Glutathione per enteric-coated tablet, a combination aimed at liver detox and antioxidant support. The formula is unflavored and comes in a 30-count bottle sized for medium and large breed dogs.
The enteric coating is designed to help the tablet move through the stomach before it breaks down, which is a common approach for ingredients that can be affected by stomach acid.
With 591 reviews at a 4.4-star average and roughly 200 purchases a month, it has built a solid track record among owners managing their dog's liver health as part of a broader care plan.
Pros
Delivers a specific 225 mg dose of SAMe plus 20 mg of glutathione per tablet
Enteric coating is designed to help the tablet survive stomach acid
Formulated specifically for medium and large breed dogs
Strong track record with 591 reviews at 4.4 stars
Cons
Not sized for small breed dogs
30-count supply is on the shorter side, meaning more frequent reordering
Should complement, not replace, veterinary treatment for a diagnosed liver condition
Specifications
Form
Tablet
Flavor
Unflavored
Benefits
Immune Support
Best for
Stomach
Breed size
Large
Weight
1.76 Ounces
Performance notes
The 225 mg SAMe and 20 mg L-glutathione combination, delivered in an enteric-coated tablet, targets liver detox pathways and antioxidant support specifically for medium and large dogs rather than a one-size-fits-all formula.
What buyers say
Nearly 600 reviews at a 4.4-star average, with about 200 purchases in the last month, suggest this is a trusted, regularly repurchased option among owners managing a dog's liver health.
No. This supplement is formulated to support liver health and antioxidant activity, not to treat or cure liver disease. Work with your vet on any diagnosed condition.
Is this suitable for small dogs?
The product is formulated for medium and large breed dogs, so check with your vet about appropriate dosing for smaller dogs.
Why is the tablet enteric coated?
The enteric coating is designed to help the tablet pass through the stomach before breaking down, which is intended to protect the ingredients before absorption.
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