Pet-Ag Esbilac Puppy Milk Replacer Powder - 12 oz - Powdered Puppy Formula with Prebiotics, Probiotics & Vitamins for Puppies Newborn to Six Weeks Old - Easy to Digest Review
By Dr. Lena Ortiz · Canine wellness writer · Published 2026-06-01 · Updated 2026-06-18
4.7(4,883)Amazon rating$25.83300+ bought last month
Our verdict
Pet-Ag Esbilac Powder is a widely used milk replacer built for newborn to six week old puppies, and with 4,883 reviews and a 4.7 star average it's one of the most established formulas in this category.
Breeders, foster caregivers, and owners bottle feeding orphaned or rejected newborn puppies, or supplementing a nursing litter.
Skip if
Your puppy is already past six weeks old and eating solid food, since this formula is built for the newborn to weaning window rather than general adult nutrition.
Form Powder
Flavor Milk
Best for Nutrition
Breed size Large
Weight 0.34 Kilograms
Our scorecard
4.7/5overall
Owner rating4.7/5
4.7 average across 4,883 owner ratings
Popularity4.2/5
4,883 owner reviews, more than most models here
The overall score is owner satisfaction weighted by how many reviews back it, so a high rating from few reviews counts for less. The bars below show where this model stands against the other dog food and health supplements we track in this category on price, popularity and size. Context, not marks against it, and our read of the data, not a lab test.
Overview
["This 12 oz container of Pet-Ag Esbilac Powder is formulated as a milk replacer for newborn to six week old puppies, mixed with water into a bottle ready formula. The label lists prebiotics, probiotics and vitamins as part of the recipe, and Pet-Ag markets it as easy to digest for young, developing digestive systems. It's sold in a bottle style container and classified as a veterinary diet product, reflecting its role as a targeted feeding solution rather than a treat or topper.", "The listing recommends it for large breeds, though breeders of other sizes commonly use Esbilac as well since the core need, replacing a mother's milk for orphaned or supplementing puppies, doesn't change much by adult size. It's also labeled wheat free, which can matter for households already managing a sensitivity elsewhere.", "At $25.83 for a 12 oz container, it's priced in line with other name brand milk replacers. What stands out is the review volume, 4,883 ratings averaging 4.7 stars, a large sample size for a specialty feeding product that suggests consistent results across a wide range of litters."]
Pros
Formulated specifically for newborn to six week old puppies, not a general supplement
Contains prebiotics, probiotics and vitamins on the label
Wheat free formula
Very strong 4.7 star average across 4,883 reviews
Sold in a resealable bottle style container
Cons
Only useful for a narrow age window, not a long term supplement
Powder must be mixed correctly, which adds a prep step versus a ready to feed liquid
Not a substitute for veterinary guidance if a puppy is failing to thrive
Specifications
Form
Powder
Flavor
Milk
Best for
Nutrition
Breed size
Large
Weight
0.34 Kilograms
Performance notes
As a powder, Esbilac needs to be reconstituted with water before feeding, which lets caregivers control concentration and mix small batches as needed, unlike a large liquid can that can spoil faster once opened. The prebiotic and probiotic additions target a newborn's developing gut, and the wheat free formulation removes one common allergen from the equation for litters or households already dealing with a sensitivity elsewhere.
What buyers say
With 4,883 reviews and a 4.7 star average, this is one of the most reviewed milk replacers in the category, and the volume suggests consistent results across many different litters and feeding situations.
Can I use Pet-Ag Esbilac Powder for a puppy older than six weeks?
The label is formulated for newborn to six week old puppies. Once a puppy is transitioning to solid food, a vet or breeder can advise on the right weaning schedule instead of continued milk replacer use.
Is this formula easy to prepare?
It's a powder that mixes with water into a bottle ready formula, so it takes an extra prep step compared to a ready to feed liquid, but that also lets you mix smaller batches as needed.
Does it contain wheat?
No, Pet-Ag lists this Esbilac Powder formula as wheat free according to the product's allergen information.
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